Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

Several HIV envelope-targeting (Env-targeting) antibodies with broad and potent neutralizing activity have been identified and shown to have unusual features. Of these, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possesses unique structural elements that...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Willis, Jordan R., Sapparapu, Gopal, Murrell, Sasha, Julien, Jean-Philippe, Singh, Vidisha, King, Hannah G., Xia, Yan, Pickens, Jennifer A., LaBranche, Celia C., Slaughter, James C., Montefiori, David C., Wilson, Ian A., Meiler, Jens, Crowe, James E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2015
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497764/
https://ncbi.nlm.nih.gov/pubmed/25985274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80693
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