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Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

A new generation of HIV broadly neutralizing antibodies (bnAbs) with remarkable potency, breadth and epitope diversity has rejuvenated interest in immunotherapeutic strategies. Potencies defined by in vitro IC(50) and IC(80) values (50 and 80% inhibitory concentrations) figure prominently into the s...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Webb, Nicholas E., Montefiori, David C., Lee, Benhur
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588098/
https://ncbi.nlm.nih.gov/pubmed/26416571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9443
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