Neutralization Breadth and Potency of Single-Chain Variable Fragments Derived from Broadly Neutralizing Antibodies Targeting Multiple Epitopes on the HIV-1 Envelope

Passive administration of HIV-directed broadly neutralizing antibodies (bNAbs) can prevent infection in animal models, and human efficacy trials are under way. Single-chain variable fragments (scFv), comprised of only the variable regions of antibody heavy and light chains, are smaller molecules tha...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: van Dorsten, Rebecca T., Lambson, Bronwen E., Wibmer, Constantinos Kurt, Weinberg, Marc S., Moore, Penny L., Morris, Lynn
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955269/
https://ncbi.nlm.nih.gov/pubmed/31619559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01533-19
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