Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

Several HIV envelope-targeting (Env-targeting) antibodies with broad and potent neutralizing activity have been identified and shown to have unusual features. Of these, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possesses unique structural elements that...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Willis, Jordan R., Sapparapu, Gopal, Murrell, Sasha, Julien, Jean-Philippe, Singh, Vidisha, King, Hannah G., Xia, Yan, Pickens, Jennifer A., LaBranche, Celia C., Slaughter, James C., Montefiori, David C., Wilson, Ian A., Meiler, Jens, Crowe, James E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497764/
https://ncbi.nlm.nih.gov/pubmed/25985274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80693
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