D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth

Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α-KG to produce D-2-hydroxyglutarate (D-2-HG), which is proposed to function as an oncometabolite by inhibiting α-KG dependent dioxygenases. We investigated the function of D-2-HG in tumorigenesis usin...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Ma, Shenghong, Jiang, Bowen, Deng, Wanglong, Gu, Zhong-Kai, Wu, Fei-Zhen, Li, Tingting, Xia, Yukun, Yang, Hui, Ye, Dan, Xiong, Yue, Guan, Kun-Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496170/
https://ncbi.nlm.nih.gov/pubmed/25825982
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