Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis

Cells are protected from toxic DNA double-stranded breaks (DSBs) by a number of DNA repair mechanisms, including some that are intrinsically error prone, thus resulting in mutations. To what extent these mechanisms contribute to evolutionary diversification remains unknown. Here, we demonstrate that...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: van Schendel, Robin, Roerink, Sophie F., Portegijs, Vincent, van den Heuvel, Sander, Tijsterman, Marcel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490562/
https://ncbi.nlm.nih.gov/pubmed/26077599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8394
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