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Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis

Cells are protected from toxic DNA double-stranded breaks (DSBs) by a number of DNA repair mechanisms, including some that are intrinsically error prone, thus resulting in mutations. To what extent these mechanisms contribute to evolutionary diversification remains unknown. Here, we demonstrate that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: van Schendel, Robin, Roerink, Sophie F., Portegijs, Vincent, van den Heuvel, Sander, Tijsterman, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490562/
https://ncbi.nlm.nih.gov/pubmed/26077599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8394
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