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Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission

The HIV envelope glycoprotein gp120 contains nine disulphide bridges and is highly glycosylated, carrying on average 24 N-linked glycans. Using a probability calculation, we here demonstrate that there is a co-localization of disulphide bridges and N-linked glycans in HIV-1 gp120, with a predominanc...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Mathys, Leen, Balzarini, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488071/
https://ncbi.nlm.nih.gov/pubmed/26121645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130621
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