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Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission

The HIV envelope glycoprotein gp120 contains nine disulphide bridges and is highly glycosylated, carrying on average 24 N-linked glycans. Using a probability calculation, we here demonstrate that there is a co-localization of disulphide bridges and N-linked glycans in HIV-1 gp120, with a predominanc...

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Publicat a:PLoS One
Autors principals: Mathys, Leen, Balzarini, Jan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488071/
https://ncbi.nlm.nih.gov/pubmed/26121645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130621
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