Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Rapidly proliferating tissues, including human tumors, use PDH to generate ener...

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Publicat a:Cancer Metab
Autors principals: Rajagopalan, Kartik N., Egnatchik, Robert A., Calvaruso, Maria A., Wasti, Ajla T., Padanad, Mahesh S., Boroughs, Lindsey K., Ko, Bookyung, Hensley, Christopher T., Acar, Melih, Hu, Zeping, Jiang, Lei, Pascual, Juan M., Scaglioni, Pier Paolo, DeBerardinis, Ralph J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487196/
https://ncbi.nlm.nih.gov/pubmed/26137220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0134-4
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