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Metabolic pathways promoting cancer cell survival and growth

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to...

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Publicat a:Nat Cell Biol
Autors principals: Boroughs, Lindsey K., DeBerardinis, Ralph J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939711/
https://ncbi.nlm.nih.gov/pubmed/25774832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3124
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