Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously demonstrated that glucose deprivation stimulated a pathway in which acetyl-CoA was formed from glutamine downstream of glutamate dehydrogenas...

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Vydáno v:Mol Cell
Hlavní autoři: Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew, Rutter, Jared, Merritt, Matthew E., DeBerardinis, Ralph J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268166/
https://ncbi.nlm.nih.gov/pubmed/25458842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.025
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