Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously demonstrated that glucose deprivation stimulated a pathway in which acetyl-CoA was formed from glutamine downstream of glutamate dehydrogenas...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew, Rutter, Jared, Merritt, Matthew E., DeBerardinis, Ralph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268166/
https://ncbi.nlm.nih.gov/pubmed/25458842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.025
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