Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Rapidly proliferating tissues, including human tumors, use PDH to generate ener...

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Détails bibliographiques
Publié dans:Cancer Metab
Auteurs principaux: Rajagopalan, Kartik N., Egnatchik, Robert A., Calvaruso, Maria A., Wasti, Ajla T., Padanad, Mahesh S., Boroughs, Lindsey K., Ko, Bookyung, Hensley, Christopher T., Acar, Melih, Hu, Zeping, Jiang, Lei, Pascual, Juan M., Scaglioni, Pier Paolo, DeBerardinis, Ralph J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487196/
https://ncbi.nlm.nih.gov/pubmed/26137220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0134-4
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