Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Rapidly proliferating tissues, including human tumors, use PDH to generate ener...

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Gepubliceerd in:Cancer Metab
Hoofdauteurs: Rajagopalan, Kartik N., Egnatchik, Robert A., Calvaruso, Maria A., Wasti, Ajla T., Padanad, Mahesh S., Boroughs, Lindsey K., Ko, Bookyung, Hensley, Christopher T., Acar, Melih, Hu, Zeping, Jiang, Lei, Pascual, Juan M., Scaglioni, Pier Paolo, DeBerardinis, Ralph J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487196/
https://ncbi.nlm.nih.gov/pubmed/26137220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0134-4
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