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Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
BACKGROUND: Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. Rapidly proliferating tissues, including human tumors, use PDH to generate ener...
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| Publié dans: | Cancer Metab |
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| Auteurs principaux: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4487196/ https://ncbi.nlm.nih.gov/pubmed/26137220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-015-0134-4 |
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