Active Pyruvate Dehydrogenase and Impaired Gluconeogenesis in Orthotopic Hepatomas of Rats

BACKGROUND: Therapies targeting altered activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) have been proposed for hepatomas. However, the activities of these pathways in hepatomas in vivo have not been distinguished. Here we examined pyruvate entry into the tricarboxylic acid (TC...

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Udgivet i:Metabolism
Main Authors: Lee, Min Hee, DeBerardinis, Ralph J., Wen, Xiaodong, Corbin, Ian R., Sherry, A. Dean, Malloy, Craig R., Jin, Eunsook S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892165/
https://ncbi.nlm.nih.gov/pubmed/31672442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.153993
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