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Active Pyruvate Dehydrogenase and Impaired Gluconeogenesis in Orthotopic Hepatomas of Rats
BACKGROUND: Therapies targeting altered activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) have been proposed for hepatomas. However, the activities of these pathways in hepatomas in vivo have not been distinguished. Here we examined pyruvate entry into the tricarboxylic acid (TC...
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| Izdano u: | Metabolism |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892165/ https://ncbi.nlm.nih.gov/pubmed/31672442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.153993 |
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