Active Pyruvate Dehydrogenase and Impaired Gluconeogenesis in Orthotopic Hepatomas of Rats

BACKGROUND: Therapies targeting altered activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) have been proposed for hepatomas. However, the activities of these pathways in hepatomas in vivo have not been distinguished. Here we examined pyruvate entry into the tricarboxylic acid (TC...

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Detaylı Bibliyografya
Yayımlandı:Metabolism
Asıl Yazarlar: Lee, Min Hee, DeBerardinis, Ralph J., Wen, Xiaodong, Corbin, Ian R., Sherry, A. Dean, Malloy, Craig R., Jin, Eunsook S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892165/
https://ncbi.nlm.nih.gov/pubmed/31672442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.153993
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