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Lactate Contributes to Glyceroneogenesis and Glyconeogenesis in Skeletal Muscle by Reversal of Pyruvate Kinase

Phosphoenolpyruvate (PEP) generated from pyruvate is required for de novo synthesis of glycerol and glycogen in skeletal muscle. One possible pathway involves synthesis of PEP from the citric acid cycle intermediates via PEP carboxykinase, whereas another could involve reversal of pyruvate kinase (P...

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Publicado en:J Biol Chem
Autores principales: Jin, Eunsook S., Sherry, A. Dean, Malloy, Craig R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683270/
https://ncbi.nlm.nih.gov/pubmed/26491014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.689174
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