Simultaneous Steady-state and Dynamic (13)C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells

Metabolic reprogramming facilitates cancer cell growth, so quantitative metabolic flux measurements could produce useful biomarkers. However, current methods to analyze flux in vivo provide either a steady-state overview of relative activities (infusion of (13)C and analysis of extracted metabolites...

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Bibliografiske detaljer
Main Authors: Yang, Chendong, Harrison, Crystal, Jin, Eunsook S., Chuang, David T., Sherry, A. Dean, Malloy, Craig R., Merritt, Matthew E., DeBerardinis, Ralph J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937686/
https://ncbi.nlm.nih.gov/pubmed/24415759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543637
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