Simultaneous Steady-state and Dynamic (13)C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells

Metabolic reprogramming facilitates cancer cell growth, so quantitative metabolic flux measurements could produce useful biomarkers. However, current methods to analyze flux in vivo provide either a steady-state overview of relative activities (infusion of (13)C and analysis of extracted metabolites...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yang, Chendong, Harrison, Crystal, Jin, Eunsook S., Chuang, David T., Sherry, A. Dean, Malloy, Craig R., Merritt, Matthew E., DeBerardinis, Ralph J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Metabolism
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937686/
https://ncbi.nlm.nih.gov/pubmed/24415759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543637
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