Simultaneous Steady-state and Dynamic (13)C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells

Metabolic reprogramming facilitates cancer cell growth, so quantitative metabolic flux measurements could produce useful biomarkers. However, current methods to analyze flux in vivo provide either a steady-state overview of relative activities (infusion of (13)C and analysis of extracted metabolites...

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Main Authors: Yang, Chendong, Harrison, Crystal, Jin, Eunsook S., Chuang, David T., Sherry, A. Dean, Malloy, Craig R., Merritt, Matthew E., DeBerardinis, Ralph J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
主題:
Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937686/
https://ncbi.nlm.nih.gov/pubmed/24415759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543637
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