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Simultaneous Steady-state and Dynamic (13)C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells

Metabolic reprogramming facilitates cancer cell growth, so quantitative metabolic flux measurements could produce useful biomarkers. However, current methods to analyze flux in vivo provide either a steady-state overview of relative activities (infusion of (13)C and analysis of extracted metabolites...

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Bibliografski detalji
Glavni autori: Yang, Chendong, Harrison, Crystal, Jin, Eunsook S., Chuang, David T., Sherry, A. Dean, Malloy, Craig R., Merritt, Matthew E., DeBerardinis, Ralph J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937686/
https://ncbi.nlm.nih.gov/pubmed/24415759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.543637
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