Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized (13)C magnetic resonance

In the heart, detection of hyperpolarized [(13)C]bicarbonate and (13)CO(2) by magnetic resonance (MR) after administration of hyperpolarized [1-(13)C]pyruvate is caused exclusively by oxidative decarboxylation of pyruvate via the pyruvate dehydrogenase complex (PDH). However, liver mitochondria poss...

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Main Authors: Merritt, Matthew E., Harrison, Crystal, Sherry, A. Dean, Malloy, Craig R., Burgess, Shawn C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223470/
https://ncbi.nlm.nih.gov/pubmed/22065779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111247108
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