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Production of hyperpolarized (13)CO(2) from [1-(13)C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production
In liver, (13)CO(2) can be generated from [1-(13)C] pyruvate via pyruvate dehydrogenase or anaplerotic entry of pyruvate into the TCA cycle followed by decarboxylation at phosphoenolpyruvate carboxykinase (PEPCK), the malic enzyme, isocitrate dehydrogenase, or α-ketoglutarate dehydrogenase. The purp...
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| Publicado no: | Metabolomics |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629494/ https://ncbi.nlm.nih.gov/pubmed/26543443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-014-0768-1 |
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