Active Pyruvate Dehydrogenase and Impaired Gluconeogenesis in Orthotopic Hepatomas of Rats

BACKGROUND: Therapies targeting altered activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) have been proposed for hepatomas. However, the activities of these pathways in hepatomas in vivo have not been distinguished. Here we examined pyruvate entry into the tricarboxylic acid (TC...

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Bibliographic Details
Published in:Metabolism
Main Authors: Lee, Min Hee, DeBerardinis, Ralph J., Wen, Xiaodong, Corbin, Ian R., Sherry, A. Dean, Malloy, Craig R., Jin, Eunsook S.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892165/
https://ncbi.nlm.nih.gov/pubmed/31672442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.153993
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