Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously demonstrated that glucose deprivation stimulated a pathway in which acetyl-CoA was formed from glutamine downstream of glutamate dehydrogenas...

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Publié dans:Mol Cell
Auteurs principaux: Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew, Rutter, Jared, Merritt, Matthew E., DeBerardinis, Ralph J.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268166/
https://ncbi.nlm.nih.gov/pubmed/25458842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.025
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