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Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously demonstrated that glucose deprivation stimulated a pathway in which acetyl-CoA was formed from glutamine downstream of glutamate dehydrogenas...
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| Wydane w: | Mol Cell |
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| Główni autorzy: | , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4268166/ https://ncbi.nlm.nih.gov/pubmed/25458842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.025 |
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