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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

Tumor cells require a constant supply of macromolecular precursors, and interrupting this supply has been proposed as a therapeutic strategy in cancer. Precursors for lipids, nucleic acids, and proteins are generated in the tricarboxylic acid (TCA) cycle and removed from the mitochondria to particip...

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Detalhes bibliográficos
Main Authors: Cheng, Tzuling, Sudderth, Jessica, Yang, Chendong, Mullen, Andrew R., Jin, Eunsook S., Matés, José M., DeBerardinis, Ralph J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102381/
https://ncbi.nlm.nih.gov/pubmed/21555572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016627108
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