Protein kinase A–dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

BACKGROUND: Dedicator of cytokinesis 1 (Dock1 or Dock180), a bipartite guanine nucleotide exchange factor for Rac1, plays critical roles in receptor tyrosine kinase–stimulated cancer growth and invasion. Dock180 activity is required in cell migration cancer tumorigenesis promoted by platelet derived...

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Vydáno v:Neuro Oncol
Hlavní autoři: Feng, Haizhong, Li, Yanxin, Yin, Yuhua, Zhang, Weiwei, Hou, Yanli, Zhang, Lei, Li, Zuoqing, Xie, Baoshu, Gao, Wei-Qiang, Sarkaria, Jann N., Raizer, Jeffery J., James, C. David, Parsa, Andrew T., Hu, Bo, Cheng, Shi-Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483118/
https://ncbi.nlm.nih.gov/pubmed/25468898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou323
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