Protein kinase A–dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

BACKGROUND: Dedicator of cytokinesis 1 (Dock1 or Dock180), a bipartite guanine nucleotide exchange factor for Rac1, plays critical roles in receptor tyrosine kinase–stimulated cancer growth and invasion. Dock180 activity is required in cell migration cancer tumorigenesis promoted by platelet derived...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Feng, Haizhong, Li, Yanxin, Yin, Yuhua, Zhang, Weiwei, Hou, Yanli, Zhang, Lei, Li, Zuoqing, Xie, Baoshu, Gao, Wei-Qiang, Sarkaria, Jann N., Raizer, Jeffery J., James, C. David, Parsa, Andrew T., Hu, Bo, Cheng, Shi-Yuan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483118/
https://ncbi.nlm.nih.gov/pubmed/25468898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou323
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