EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180

Glioblastomas (GBMs), the most common and malignant brain tumors, are highly resistant to current therapies. The failure of targeted therapies against aberrantly activated oncogenic signaling, such as that of the EGFR-PI3K/Akt pathway, underscores the urgent need to understand alternative downstream...

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Bibliografiske detaljer
Main Authors: Feng, Haizhong, Hu, Bo, Vuori, Kristiina, Sarkaria, Jann N., Furnari, Frank B., Cavenee, Webster K., Cheng, Shi-Yuan
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883905/
https://ncbi.nlm.nih.gov/pubmed/23728337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.198
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