Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

Two hallmarks of glioblastoma multiforme, the most common malignant brain cancer in humans, are aggressive growth and the ability of single glioma cells to disperse throughout the brain. These characteristics render tumors resistant to current therapies and account for the poor prognosis of patients...

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Detalhes bibliográficos
Main Authors: Feng, Haizhong, Hu, Bo, Liu, Kun-Wei, Li, Yanxin, Lu, Xinghua, Cheng, Tao, Yiin, Jia-Jean, Lu, Songjian, Keezer, Susan, Fenton, Tim, Furnari, Frank B., Hamilton, Ronald L., Vuori, Kristiina, Sarkaria, Jann N., Nagane, Motoo, Nishikawa, Ryo, Cavenee, Webster K., Cheng, Shi-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223070/
https://ncbi.nlm.nih.gov/pubmed/22080864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58559
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