Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2–mediated signaling

BACKGROUND: Glioblastoma (GBM) is the most malignant primary brain tumor, with dismal median survival. Treatment of GBM is particularly challenging given the intrinsic resistance to chemotherapy and difficulty of drugs to reach the tumor beds due to the blood–brain barrier. Here, we examined the eff...

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Библиографические подробности
Опубликовано в: :Neuro Oncol
Главные авторы: Sang, Youzhou, Hou, Yanli, Cheng, Rongrong, Zheng, Liang, Alvarez, Angel A, Hu, Bo, Cheng, Shi-Yuan, Zhang, Weiwei, Li, Yanxin, Feng, Haizhong
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Basic and Translational Investigations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827835/
https://ncbi.nlm.nih.gov/pubmed/31232447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz107
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