Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2–mediated signaling

BACKGROUND: Glioblastoma (GBM) is the most malignant primary brain tumor, with dismal median survival. Treatment of GBM is particularly challenging given the intrinsic resistance to chemotherapy and difficulty of drugs to reach the tumor beds due to the blood–brain barrier. Here, we examined the eff...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Sang, Youzhou, Hou, Yanli, Cheng, Rongrong, Zheng, Liang, Alvarez, Angel A, Hu, Bo, Cheng, Shi-Yuan, Zhang, Weiwei, Li, Yanxin, Feng, Haizhong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827835/
https://ncbi.nlm.nih.gov/pubmed/31232447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz107
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