An allosteric inhibitor of SHP2 effectively targets PDGFRα-driven glioblastoma

Lignende værker

• Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2–mediated signaling
  af: Sang, Youzhou, et al.
  Udgivet: (2019)
• Dynamin 2 Mediates PDGFRα-SHP-2-Promoted Glioblastoma Growth and Invasion
  af: Feng, H, et al.
  Udgivet: (2011)
• SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial–mesenchymal transition and invasion in mice and humans
  af: Zhang, L, et al.
  Udgivet: (2016)
• A TNF-NF-κB-STAT3 loop triggers resistance of glioma-stem-like cells to Smac mimetics while sensitizing to EZH2 inhibitors
  af: Tannous, Bakhos A., et al.
  Udgivet: (2019)
• Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
  af: Sun, X, et al.
  Udgivet: (2018)