SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial–mesenchymal transition and invasion in mice and humans

Gliomas are highly malignant brain tumors that are highly invasive and resistant to conventional therapy. Receptor tyrosine kinases (RTKs) such as PDGFRα (platelet-derived growth factor receptor-α), which show frequent aberrant activation in gliomas, are associated with a process of epithelial–mesen...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhang, L, Zhang, W, Li, Y, Alvarez, A, Li, Z, Wang, Y, Song, L, Lv, D, Nakano, I, Hu, B, Cheng, S-Y, Feng, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050071/
https://ncbi.nlm.nih.gov/pubmed/27041571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.100
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