SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial–mesenchymal transition and invasion in mice and humans

Gliomas are highly malignant brain tumors that are highly invasive and resistant to conventional therapy. Receptor tyrosine kinases (RTKs) such as PDGFRα (platelet-derived growth factor receptor-α), which show frequent aberrant activation in gliomas, are associated with a process of epithelial–mesen...

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Dettagli Bibliografici
Pubblicato in:Oncogene
Autori principali: Zhang, L, Zhang, W, Li, Y, Alvarez, A, Li, Z, Wang, Y, Song, L, Lv, D, Nakano, I, Hu, B, Cheng, S-Y, Feng, H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050071/
https://ncbi.nlm.nih.gov/pubmed/27041571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.100
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