Sirolimus for progressive neurofibromatosis type 1–associated plexiform neurofibromas: a Neurofibromatosis Clinical Trials Consortium phase II study

BACKGROUND: Plexiform neurofibromas (PNs) are benign peripheral nerve sheath tumors that arise in one-third of individuals with neurofibromatosis type 1 (NF1). They may cause significant disfigurement, compression of vital structures, neurologic dysfunction, and/or pain. Currently, the only effectiv...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Weiss, Brian, Widemann, Brigitte C., Wolters, Pamela, Dombi, Eva, Vinks, Alexander, Cantor, Alan, Perentesis, John, Schorry, Elizabeth, Ullrich, Nicole, Gutmann, David H., Tonsgard, James, Viskochil, David, Korf, Bruce, Packer, Roger J., Fisher, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Pediatric Neuro-Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483073/
https://ncbi.nlm.nih.gov/pubmed/25314964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou235
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