NFM-06. NF106: PHASE 2 TRIAL OF THE MEK INHIBITOR PD-0325901 IN ADOLESCENTS AND ADULTS WITH NF1-RELATED PLEXIFORM NEUROFIBROMAS: AN NF CLINICAL TRIALS CONSORTIUM STUDY

Plexiform neurofibromas (PNs) can cause significant disfigurement, compression of vital structures, neurologic dysfunction, and pain. MEK pathway inhibition results in significant PN shrinkage in neurofibromatosis type 1 (NF1) mouse models of PN. We evaluated the efficacy of the MEK inhibitor, PD032...

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Publicat a:Neuro Oncol
Autors principals: Weiss, Brian, Plotkin, Scott, Widemann, Brigitte, Tonsgard, James, Blakeley, Jaishri, Allen, Jeffrey, Schorry, Elizabeth, Korf, Bruce, Rosser, Tena, Goldman, Stewart, Vinks, Alexander, Cutter, Gary, Dombi, Eva, Ratner, Nancy, Packer, Roger, Fisher, Michael
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012484/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.514
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