NFM-01. NF105: A PHASE II PROSPECTIVE STUDY OF CABOZANTINIB (XL184) FOR PLEXIFORM NEUROFIBROMAS IN SUBJECTS WITH NEUROFIBROMATOSIS TYPE 1: A NEUROFIBROMATOSIS CLINICAL TRIAL CONSORTIUM (NFCTC) STUDY

BACKGROUND: Plexiform neurofibromas (PNs) are histologically complex peripheral nerve sheath tumors composed of Schwann cells and fibrocytes. Pre-clinical models have demonstrated that altering the microenvironment with molecular targeting therapy may lead to the shrinkage of PN. Here we test the ac...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Shih, Chie-Schin, Blakely, Jaishri, Clapp, Wade, Wolters, Pam, Dombi, Eva, Cutter, Gary, Ullrich, Nichole, Allen, Jeffrey, Packer, Roger, Goldman, Stewart, Gutmann, David, Plotkin, Scott, Rosser, Tena, Robertson, Kent, Widemann, Brigitte, Korf, Bruce, Fisher, Michael
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
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Abstracts
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011904/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.510
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