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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein C, respectively. Numerous previous studies have shown that electropositive regions at a distance from the active site,...
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| Udgivet i: | PLoS One |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4482499/ https://ncbi.nlm.nih.gov/pubmed/26110612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129511 |
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