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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein C, respectively. Numerous previous studies have shown that electropositive regions at a distance from the active site,...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Chahal, Gurdeep, Thorpe, Michael, Hellman, Lars
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482499/
https://ncbi.nlm.nih.gov/pubmed/26110612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129511
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