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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein C, respectively. Numerous previous studies have shown that electropositive regions at a distance from the active site,...
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| 出版年: | PLoS One |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4482499/ https://ncbi.nlm.nih.gov/pubmed/26110612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129511 |
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