BLM unfolds G-quadruplexes in different structural environments through different mechanisms

Mutations in the RecQ DNA helicase gene BLM give rise to Bloom's syndrome, which is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition. BLM helicase is highly active in binding and unwinding G-quadruplexes (G4s), which are physiological targets fo...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Wu, Wen-Qiang, Hou, Xi-Miao, Li, Ming, Dou, Shuo-Xing, Xi, Xu-Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482088/
https://ncbi.nlm.nih.gov/pubmed/25897130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv361
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