Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures

Bloom (BLM) syndrome is an autosomal recessive disorder characterized by an increased risk for many types of cancers. Previous studies have shown that BLM protein forms a hexameric ring structure, but its oligomeric form in DNA unwinding is still not well clarified. In this work, we have used dynami...

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Detalhes bibliográficos
Main Authors: Xu, Ya-Nan, Bazeille, Nicolas, Ding, Xiu-Yan, Lu, Xi-Ming, Wang, Peng-Ye, Bugnard, Elisabeth, Grondin, Virginie, Dou, Shuo-Xing, Xi, Xu Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479192/
https://ncbi.nlm.nih.gov/pubmed/22885301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks728
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