Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures

Bloom (BLM) syndrome is an autosomal recessive disorder characterized by an increased risk for many types of cancers. Previous studies have shown that BLM protein forms a hexameric ring structure, but its oligomeric form in DNA unwinding is still not well clarified. In this work, we have used dynami...

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Autors principals: Xu, Ya-Nan, Bazeille, Nicolas, Ding, Xiu-Yan, Lu, Xi-Ming, Wang, Peng-Ye, Bugnard, Elisabeth, Grondin, Virginie, Dou, Shuo-Xing, Xi, Xu Guang
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479192/
https://ncbi.nlm.nih.gov/pubmed/22885301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks728
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