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Low Affinity and Slow Na(+) Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter Glt(Ph)

Glt(Ph) from Pyrococcus horikoshii is a homotrimeric Na(+)-coupled aspartate transporter. It belongs to the widespread family of glutamate transporters, which also includes the mammalian excitatory amino acid transporters that take up the neurotransmitter glutamate. Each protomer in Glt(Ph) consists...

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Vydáno v:J Biol Chem
Hlavní autoři: Hänelt, Inga, Jensen, Sonja, Wunnicke, Dorith, Slotboom, Dirk Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481202/
https://ncbi.nlm.nih.gov/pubmed/25922069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656876
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