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Low Affinity and Slow Na(+) Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter Glt(Ph)

Glt(Ph) from Pyrococcus horikoshii is a homotrimeric Na(+)-coupled aspartate transporter. It belongs to the widespread family of glutamate transporters, which also includes the mammalian excitatory amino acid transporters that take up the neurotransmitter glutamate. Each protomer in Glt(Ph) consists...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hänelt, Inga, Jensen, Sonja, Wunnicke, Dorith, Slotboom, Dirk Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481202/
https://ncbi.nlm.nih.gov/pubmed/25922069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656876
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