Low Affinity and Slow Na(+) Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter Glt(Ph)

Glt(Ph) from Pyrococcus horikoshii is a homotrimeric Na(+)-coupled aspartate transporter. It belongs to the widespread family of glutamate transporters, which also includes the mammalian excitatory amino acid transporters that take up the neurotransmitter glutamate. Each protomer in Glt(Ph) consists...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hänelt, Inga, Jensen, Sonja, Wunnicke, Dorith, Slotboom, Dirk Jan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481202/
https://ncbi.nlm.nih.gov/pubmed/25922069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656876
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