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Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein

Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement. In wild-type mice whose mouse FH does not bind to FHbp vaccines, the serum anti-FHbp antibody response inhibited binding of human FH to FH...

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Bibliografske podrobnosti
izdano v:mBio
Main Authors: Beernink, Peter T., Giuntini, Serena, Costa, Isabella, Lucas, Alexander H., Granoff, Dan M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479705/
https://ncbi.nlm.nih.gov/pubmed/26106082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00842-15
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