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Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding

Meningococcal factor H-binding protein (FHbp) is an antigen in 2 serogroup B meningococcal vaccines. FHbp specifically binds human and some nonhuman primate complement FH. To investigate the effect of binding of FH to FHbp on protective antibody responses, we immunized infant rhesus macaques with ei...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Granoff, Dan M., Giuntini, Serena, Gowans, Flor A., Lujan, Eduardo, Sharkey, Kelsey, Beernink, Peter T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033880/
https://ncbi.nlm.nih.gov/pubmed/27668287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88907
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