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Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding
Meningococcal factor H-binding protein (FHbp) is an antigen in 2 serogroup B meningococcal vaccines. FHbp specifically binds human and some nonhuman primate complement FH. To investigate the effect of binding of FH to FHbp on protective antibody responses, we immunized infant rhesus macaques with ei...
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| Pubblicato in: | JCI Insight |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033880/ https://ncbi.nlm.nih.gov/pubmed/27668287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88907 |
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