Monoclonal Antibodies to Meningococcal Factor H Binding Protein with Overlapping Epitopes and Discordant Functional Activity

BACKGROUND: Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated bactericidal activity directly. The antibodies also can block binding of the human complement down-regulator, factor H (fH). Withou...

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Hlavní autoři: Giuntini, Serena, Beernink, Peter T., Reason, Donald C., Granoff, Dan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312907/
https://ncbi.nlm.nih.gov/pubmed/22461909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034272
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