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Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein

Meningococcal vaccines containing factor H binding protein (fHbp) are in clinical development. fHbp binds human fH, which enables the meningococcus to resist complement-mediated bacteriolysis. Previously, we found that chimeric human IgG1 mouse anti-fHbp monoclonal antibodies (MAbs) had human comple...

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Bibliografske podrobnosti
Main Authors: Giuntini, Serena, Reason, Donald C., Granoff, Dan M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255668/
https://ncbi.nlm.nih.gov/pubmed/22064712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05956-11
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