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Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the Target Antigen and Epitope Specificity

We compared the bactericidal activity of recombinant sets of chimeric IgG monoclonal antibodies against two important outer membrane meningococcal vaccine antigens: PorA and factor H binding protein (FHbp). The sets contained human Fc portions from IgG1, IgG3, and two IgG3 mutants (IgG3m15 and IgGm1...

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Bibliografische gegevens
Gepubliceerd in:Clin Vaccine Immunol
Hoofdauteurs: Giuntini, S., Granoff, D. M., Beernink, P. T., Ihle, O., Bratlie, D., Michaelsen, T. E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979173/
https://ncbi.nlm.nih.gov/pubmed/27307451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00193-16
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