Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies

Antibody functions such as neutralization require recognition of antigen by the Fab region, while effector functions are additionally mediated by interactions of the Fc region with soluble factors and cellular receptors. The efficacy of individual antibodies varies based on Fab domain characteristic...

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發表在:PLoS Pathog
Main Authors: Chu, Thach H., Crowley, Andrew R., Backes, Iara, Chang, Cheryl, Tay, Matthew, Broge, Thomas, Tuyishime, Marina, Ferrari, Guido, Seaman, Michael S., Richardson, Simone I., Tomaras, Georgia D., Alter, Galit, Leib, David, Ackerman, Margaret E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058349/
https://ncbi.nlm.nih.gov/pubmed/32092122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008083
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