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Coming together at the hinges: Therapeutic prospects of IgG3

The human IgG3 subclass is conspicuously absent among the formats for approved monoclonal antibody therapies and Fc fusion protein biologics. Concern about the potential for rapid degradation, reduced plasma half-life, and increased immunogenicity due to marked variation in allotypes has apparently...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:MAbs
Main Authors: Chu, Thach H., Patz, Edward F., Ackerman, Margaret E.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899677/
https://ncbi.nlm.nih.gov/pubmed/33602056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2021.1882028
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