Highly parallel characterization of IgG Fc binding interactions

Because the variable ability of the antibody constant (Fc) domain to recruit innate immune effector cells and complement is a major factor in antibody activity in vivo, convenient means of assessing these binding interactions is of high relevance to the development of enhanced antibody therapeutics,...

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Detalhes bibliográficos
Main Authors: Boesch, Austin W, Brown, Eric P, Cheng, Hao D, Ofori, Maame Ofua, Normandin, Erica, Nigrovic, Peter A, Alter, Galit, Ackerman, Margaret E
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171026/
https://ncbi.nlm.nih.gov/pubmed/24927273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28808
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