Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the Target Antigen and Epitope Specificity

We compared the bactericidal activity of recombinant sets of chimeric IgG monoclonal antibodies against two important outer membrane meningococcal vaccine antigens: PorA and factor H binding protein (FHbp). The sets contained human Fc portions from IgG1, IgG3, and two IgG3 mutants (IgG3m15 and IgGm1...

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Bibliographic Details
Published in:Clin Vaccine Immunol
Main Authors: Giuntini, S., Granoff, D. M., Beernink, P. T., Ihle, O., Bratlie, D., Michaelsen, T. E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979173/
https://ncbi.nlm.nih.gov/pubmed/27307451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00193-16
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