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Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding

Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H binding protein (fHbp) is an important ligand for human fH. While some fHbp-specific monoclonal an...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Giuntini, Serena, Reason, Donald C., Granoff, Dan M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165461/
https://ncbi.nlm.nih.gov/pubmed/21708990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05182-11
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