A Herpes Simplex Virus Type 1 Human Asymptomatic CD8(+) T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a “Humanized” HLA Transgenic Rabbit Model

PURPOSE. A clinical vaccine that protects from ocular herpes simplex virus type 1 (HSV-1) infection and disease still is lacking. In the present study, preclinical vaccine trials of nine asymptomatic (ASYMP) peptides, selected from HSV-1 glycoproteins B (gB), and tegument proteins VP11/12 and VP13/1...

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Sparad:
Bibliografiska uppgifter
I publikationen:Invest Ophthalmol Vis Sci
Huvudupphovsmän: Srivastava, Ruchi, Khan, Arif A., Huang, Jiawei, Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Association for Research in Vision and Ophthalmology 2015
Ämnen:
Immunology and Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477261/
https://ncbi.nlm.nih.gov/pubmed/26098469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17074
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