Therapeutic Immunization with a Mixture of Herpes Simplex Virus 1 Glycoprotein D-Derived “Asymptomatic” Human CD8(+) T-Cell Epitopes Decreases Spontaneous Ocular Shedding in Latently Infected HLA Transgenic Rabbits: Association with Low Frequency of Local PD-1(+) TIM-3(+) CD8(+) Exhausted T Cells

Most blinding ocular herpetic disease is due to reactivation of herpes simplex virus 1 (HSV-1) from latency rather than to primary acute infection. No herpes simplex vaccine is currently available for use in humans. In this study, we used the HLA-A*02:01 transgenic (HLA Tg) rabbit model of ocular he...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Khan, Arif A., Srivastava, Ruchi, Chentoufi, Aziz A., Geertsema, Roger, Thai, Nhi Thi Uyen, Dasgupta, Gargi, Osorio, Nelson, Kalantari, Mina, Nesburn, Anthony B., Wechsler, Steven L., BenMohamed, Lbachir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468472/
https://ncbi.nlm.nih.gov/pubmed/25878105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00788-15
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